Internet Archive Search: creator:"Doyle, Francis J."

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Vol 7: Estimating confidence intervals in predicted responses for oscillatory biological models.

Oct 24, 2014 10/14

by St John, Peter C; Doyle, Francis J

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This article is from BMC Systems Biology , volume 7 . Abstract Background: The dynamics of gene regulation play a crucial role in a cellular control: allowing the cell to express the right proteins to meet changing needs. Some needs, such as correctly anticipating the day-night cycle, require complicated oscillatory features. In the analysis of gene regulatory networks, mathematical models are frequently used to understand how a network’s structure enables it to respond appropriately to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3733791

PubMed Central

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Vol 13: Core module biomarker identification with network exploration for breast cancer metastasis.

Oct 29, 2014 10/14

by Yang, Ruoting; Daigle, Bernie J; Petzold, Linda R; Doyle, Francis J

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This article is from BMC Bioinformatics , volume 13 . Abstract Background: In a complex disease, the expression of many genes can be significantly altered, leading to the appearance of a differentially expressed "disease module". Some of these genes directly correspond to the disease phenotype, (i.e. "driver" genes), while others represent closely-related first-degree neighbours in gene interaction space. The remaining genes consist of further removed "passenger"...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3349569

PubMed Central

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Vol 4: Quantity and accessibility for specific targeting of receptors in tumours.

Oct 21, 2014 10/14

by Hussain, Sajid; Rodriguez-Fernandez, Maria; Braun, Gary B.; Doyle, Francis J.; Ruoslahti, Erkki

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This article is from Scientific Reports , volume 4 . Abstract Synaphic (ligand-directed) targeting of drugs is an important potential new approach to drug delivery, particularly in oncology. Considerable success with this approach has been achieved in the treatment of blood-borne cancers, but the advances with solid tumours have been modest. Here, we have studied the number and availability for ligand binding of the receptors for two targeting ligands. The results show that both paucity of...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4050384

PubMed Central

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Vol 7: Core modular blood and brain biomarkers in social defeat mouse model for post traumatic stress disorder.

Oct 24, 2014 10/14

by Yang, Ruoting; Daigle Jr, Bernie J; Muhie, Seid Y; Hammamieh, Rasha; Jett, Marti; Petzold, Linda; Doyle, Francis J

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This article is from BMC Systems Biology , volume 7 . Abstract Background: Post-traumatic stress disorder (PTSD) is a severe anxiety disorder that affects a substantial portion of combat veterans and poses serious consequences to long-term health. Consequently, the identification of diagnostic and prognostic blood biomarkers for PTSD is of great interest. Previously, we assessed genome-wide gene expression of seven brain regions and whole blood in a social defeat mouse model subjected to...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3751782

PubMed Central

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Vol 36: Clinical Evaluation of a Personalized Artificial Pancreas.

Oct 23, 2014 10/14

by Dassau, Eyal; Zisser, Howard; Harvey, Rebecca A.; Percival, Matthew W.; Grosman, Benyamin; Bevier, Wendy; Atlas, Eran; Miller, Shahar; Nimri, Revital; Jovanovic, Lois; Doyle, Francis J.

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This article is from Diabetes Care , volume 36 . Abstract OBJECTIVE: An artificial pancreas (AP) that automatically regulates blood glucose would greatly improve the lives of individuals with diabetes. Such a device would prevent hypo- and hyperglycemia along with associated long- and short-term complications as well as ease some of the day-to-day burden of frequent blood glucose measurements and insulin administration. RESEARCH DESIGN AND METHODS: We conducted a pilot clinical trial evaluating...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3609541

PubMed Central

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Vol 33: Real-Time Hypoglycemia Prediction Suite Using Continuous Glucose Monitoring: A safety net for the artificial pancreas.

Oct 24, 2014 10/14

by Dassau, Eyal; Cameron, Fraser; Lee, Hyunjin; Bequette, B. Wayne; Zisser, Howard; Jovanovic, Lois; Chase, H. Peter; Wilson, Darrell M.; Buckingham, Bruce A.; Doyle, Francis J.

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This article is from Diabetes Care , volume 33 . Abstract OBJECTIVE: The purpose of this study was to develop an advanced algorithm that detects pending hypoglycemia and then suspends basal insulin delivery. This approach can provide a solution to the problem of nocturnal hypoglycemia, a major concern of patients with diabetes. RESEARCH DESIGN AND METHODS: This real-time hypoglycemia prediction algorithm (HPA) combines five individual algorithms, all based on continuous glucose monitoring 1-min...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2875433

PubMed Central

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Vol 36: Feasibility of Outpatient Fully Integrated Closed-Loop Control: First studies of wearable artificial pancreas.

Oct 18, 2014 10/14

by Kovatchev, Boris P.; Renard, Eric; Cobelli, Claudio; Zisser, Howard C.; Keith-Hynes, Patrick; Anderson, Stacey M.; Brown, Sue A.; Chernavvsky, Daniel R.; Breton, Marc D.; Farret, Anne; Pelletier, Marie-Josee; Place, Jerome; Bruttomesso, Daniela; Del Favero, Simone; Visentin, Roberto; Filippi, Alessio; Scotton, Rachele; Avogaro, Angelo; Doyle, Francis J.

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This article is from Diabetes Care , volume 36 . Abstract OBJECTIVE: To evaluate the feasibility of a wearable artificial pancreas system, the Diabetes Assistant (DiAs), which uses a smart phone as a closed-loop control platform. RESEARCH DESIGN AND METHODS: Twenty patients with type 1 diabetes were enrolled at the Universities of Padova, Montpellier, and Virginia and at Sansum Diabetes Research Institute. Each trial continued for 42 h. The United States studies were conducted entirely in...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3687268

PubMed Central

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Vol 61: Fully Integrated Artificial Pancreas in Type 1 Diabetes: Modular Closed-Loop Glucose Control Maintains Near Normoglycemia.

Oct 28, 2014 10/14

by Breton, Marc; Farret, Anne; Bruttomesso, Daniela; Anderson, Stacey; Magni, Lalo; Patek, Stephen; Dalla Man, Chiara; Place, Jerome; Demartini, Susan; Del Favero, Simone; Toffanin, Chiara; Hughes-Karvetski, Colleen; Dassau, Eyal; Zisser, Howard; Doyle, Francis J.; De Nicolao, Giuseppe; Avogaro, Angelo; Cobelli, Claudio; Renard, Eric; Kovatchev, Boris

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This article is from Diabetes , volume 61 . Abstract : Integrated closed-loop control (CLC), combining continuous glucose monitoring (CGM) with insulin pump (continuous subcutaneous insulin infusion [CSII]), known as artificial pancreas, can help optimize glycemic control in diabetes. We present a fundamental modular concept for CLC design, illustrated by clinical studies involving 11 adolescents and 27 adults at the Universities of Virginia, Padova, and Montpellier. We tested two modular CLC...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3425406

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